President Obama will pay his respects to Oprah on April 27.
The Commander-in-Chief and Michelle Obama are set to tape a farewell interview at Harpo Studios with the talk show queen, whose final show is May 25.
The Obamas will then remain in Chicago for three fundraisers.
The First Family has a long history with fellow Chicagoan Oprah, who campaigned on their behalf in 2008.
Last August, the talk show host was among the guests at a small birthday celebration for President Obama at Graham Elliot, a restaurant in Chicago.
Oprah’s interview with President and Mrs. Obama will air on May 2.